SIRIAMLAB
PLEXUSLumbarLumbosacralEstablished

Plexus Lumbosacralis DUO

Transition concept for the lumbosacral field, where lumbar and sacral territories meet across the pelvic rim.

Formulated for the broad transition band in which the lower lumbar segments hand over to the sacral plexus, following the surface projection across the iliac crest and the posterior pelvic rim.

QR code printed on the Plexus Lumbosacralis DUO label

Label QR

Opens the public information page in the reader's language.

https://www.siriamlab.com/qr/plexus-lumbosacralis-duo

Open patient page
← Essential overview

Complete scientific monograph: anatomy, formulation architecture, references and revision record.

Chapter 01

Product identity

Identification, classification, family, intended use, anatomical region and the documents this record is governed by.

Identification of the record: product identifier, classification, family, intended use, anatomical region and the controlled documents it is governed by.

Documentation metadata+

Chapter 01 — related anatomy

lumbar

Related documents

PF-PLS-1.0Plexus Lumbosacralis DUO — product formula cardIn preparation

Future references

  • GTIN / label identifierReservedCommercial identifier reserved for the published label.

Record identification

DocumentedVersion1.0
Product ID
SIR-PLS-01
Family
PLEXUS LUMBOSACRALIS DUO
Region
Lumbosacral — pelvic rim transition
Last update
2025-09

Handbook source

HB-PLSApproved

Neurodermal, myofascial and neurovegetative modulation of the plexus lumbosacralis (L4–S2), EMG targeted.

  • Phase 1: afferent discharge of the L4–S2 field and gluteal / piriformis tension
  • Phase 2: stabilisation, fascial integration and vegetative harmonisation
Developer
MT DO, DCP
Pharmacist
AVA
Chapter version
1.0
Product ID
SIR-PLS-01

The handbook is the scientific master. Every statement rendered on this record originates from this chapter; the platform never creates independent scientific content.

Chapter 02

Executive summary

The record in short: professional summary, patient summary and the sequential treatment model behind it.

The record read in short: professional summary, patient summary and the sequential treatment model behind the formulation.

Documentation metadata+

Chapter 02 — related anatomy

Declared; content in preparation.

Related documents

SDR-001SIRIAM digital record standard

Future references

  • TranslationsReservedExecutive summary in Dutch, French and German.

Executive summary

SDR-001

The reading entry of the record: what the composition is for, in professional and in patient language.

Purpose

Supports a structured routine across a field that is otherwise difficult to define, by anchoring the application to two reproducible bony landmarks.

Clinical goal

Segmental orientationStructured daily applicationProfessional protocol support

Primary anatomical region

lumbar

Primary therapeutic objective

Documented cutaneous topical composition for the lumbosacral transition field.

Professional summary

Plexus Lumbosacralis DUO is documented as a cutaneous topical composition for the lumbar application field. This summary is maintained by the documentation team and updated with each revision of the record.

Patient summary

Transition concept for the lumbosacral field, where lumbar and sacral territories meet across the pelvic rim.

Keywords

Plexus Lumbosacralis DUOPLEXUSlumbarL4L5S1S2lumbarsacral

Chapter 03

Anatomy snapshot

The anatomical region of the record and every structure of its application field, resolving into the Neuro Atlas.

The anatomical identity of the record: the region, the segmental levels and the surface territory the formulation is documented for.

Documentation metadata+

Chapter 03 — related anatomy

lumbarL4L5S1S2

Future references

  • 3D Atlas referenceReservedVolumetric reference of the field, prepared for the atlas engine.
  • EMG referenceReservedFunctional EMG dataset linked to the segmental levels of this record.
  • SRST referenceReservedSegmental reflex surface topography mapping.

Snapshot

Anatomy snapshot

Six metameric expressions per segment — dermatome, myotome, sclerotome, viscerotome, micro-angiotome and neurotome. Individual structures inside an expression open their own illustration plate.

Anatomical regionLumbar · Lumbosacral field
DermatomesL4L5S1S2
MetamersL4L5S1S2
Application zonesIliac crest linePosterior superior iliac spineUpper gluteal quadrantSacroiliac projection
Clinical objectiveSegmental orientation · Structured daily application · Professional protocol support
Application systemSingle-phase formulation
Atlas layersBody regionsDermatomesPeripheral nervesPlexusesMetamersNeurocutaneous

Anatomy

Anatomical overview

The application field of Plexus Lumbosacralis DUO is described through its dermatomes, peripheral nerves, plexus relations and metameric levels. Each object below resolves to the corresponding structure in the Neuro Atlas.

  • LumbarThoracolumbar junction and lumbar plexus projection field, extending toward the anterior thigh.Body regionAtlas →
  • 4 dermatomes · 4 metamersSegmental objects linked to this record.Segmental scope
  • 3 peripheral nervesSurface territories referenced by the application field.Peripheral scope

Segmental

Dermatomes

  • L4Medial leg and medial malleolus.DermatomeAtlas →
  • L5Lateral leg and dorsum of the foot.DermatomeAtlas →
  • S1Lateral foot border and posterior calf.DermatomeAtlas →
  • S2Posterior thigh strip and posterior calf.DermatomeAtlas →

Segmental

Peripheral nerves

  • Sciatic nervePosterior thigh, dividing into tibial and fibular territories.Peripheral nerveAtlas →
  • Superior gluteal nerveGluteal field above the piriformis line.Peripheral nerveAtlas →
  • Pudendal nervePerineal and lower sacral surface.Peripheral nerveAtlas →

Segmental

Plexus relations

  • Lumbar plexusFormed within the psoas major, supplying the lower abdominal wall and anterior thigh.Roots L1–L4Atlas →
  • Sacral plexusLocated on the posterior pelvic wall, giving rise to the largest nerve of the body.Roots L4–S4Atlas →

Segmental

Metamers

Professional mode

Segmental links are protected.

Metameric cross-references are reserved for practitioners trained in segmental reasoning. Enter your professional code to continue.

Segmental

Neurocutaneous regions

  • Lumbosacral neurocutaneous zoneTransition between lumbar and sacral surface projections across the pelvic rim.L5 · S1Atlas →
  • Sacral neurocutaneous zonePosterior pelvic base, mapped to the S1–S4 surface projection field.S1 · S2 · S3 · S4Atlas →

Anatomical identity

Chapter 01

Primary region

lumbar

Dermatomes

L4L5S1S2

Peripheral nerves

sciaticsuperior-glutealpudendal

Plexus

lumbarsacral

Metamers

L4L5S1S2

Neurocutaneous territories

lumbosacralsacral

Body regions

lumbar

Surface anatomy

Iliac crest linePosterior superior iliac spineUpper gluteal quadrantSacroiliac projection
  • 3D Atlas referenceReservedVolumetric field reference.
  • EMG referenceReservedFunctional EMG dataset.
  • SRST referenceReservedSegmental reflex surface topography.

Chapter 04

Clinical purpose

Objective, strategy, workflow and the boundaries within which this record is documented.

The clinical objective of the record, its rationale, and the boundaries within which it is documented.

Documentation metadata+

Chapter 04 — related anatomy

lumbosacralsacral

Future references

  • Evidence levelReservedGraded evidence classification per documented statement.
  • Clinical casesReservedStructured practitioner observations linked to this record.

Purpose

Why this formulation exists

Plexus Lumbosacralis DUO is documented as a cutaneous topical composition for the lumbar application field. This summary is maintained by the documentation team and updated with each revision of the record.

Why this record exists

Supports a structured routine across a field that is otherwise difficult to define, by anchoring the application to two reproducible bony landmarks.

Neurocutaneous region it was designed for

Lumbosacral neurocutaneous zone · Sacral neurocutaneous zone

Anatomical interface it addresses

Thoracolumbar junction and lumbar plexus projection field, extending toward the anterior thigh.

Clinical philosophy

The lumbosacral trunk carries L4 and L5 fibres into the sacral plexus. Its surface correlate is a diagonal band rather than a single dermatome, which is why the application field is described by landmarks instead of segments alone.

  • The field spans two plexus territories; document which landmark line was used so sessions remain comparable.
  • Cutaneous topical composition; the application field is defined by the treating professional.

Chapter 05

Application protocol

Timeline, application sites, professional and patient instructions, safety and storage.

Phases, cadence, duration, zone order and the documented application sequence, with practitioner and patient notes.

Documentation metadata+

Chapter 05 — related anatomy

Iliac crest linePosterior superior iliac spineUpper gluteal quadrantSacroiliac projection

Future references

  • Printable protocolReservedPrint-ready protocol sheet generated from this record.

Surface

Application zones

The zones listed are possible application locations. The practitioner identifies the exact spot within these possibilities using the SRST (Segmental Reflex Sensitisation Test). Future evaluation will use EMG before and after application.

  • Iliac crest line

    Detailed application guidance is in preparation.

    Application field
  • Posterior superior iliac spine

    Detailed application guidance is in preparation.

    Application field
  • Upper gluteal quadrant

    Detailed application guidance is in preparation.

    Application field
  • Sacroiliac projection

    Detailed application guidance is in preparation.

    Application field
Segmental orientationStructured daily applicationProfessional protocol support

Protocol

Application protocol

  1. Application

    Single-phase application

    1–2 applications per day

    Defined observation period

    One thin layer is applied across the documented field, following the same sequence at every session.

    Iliac crest linePosterior superior iliac spineUpper gluteal quadrantSacroiliac projection
  2. Maintenance

    Continued routine

    1–3 sessions per week

    Ongoing, reviewed periodically

    The routine is continued at a reduced cadence and reviewed with the practitioner at agreed intervals. Observations stay in the professional log so successive periods remain comparable.

    Iliac crest linePosterior superior iliac spineUpper gluteal quadrantSacroiliac projection

Zone sequence

  1. 01Iliac crest line
  2. 02Posterior superior iliac spine
  3. 03Upper gluteal quadrant
  4. 04Sacroiliac projection
  1. 01Identify the posterior superior iliac spines as the reference line.
  2. 02Apply along the iliac crest toward the sacroiliac projection.
  3. 03Cover the upper gluteal quadrant with even, unhurried passes.

Application field on the atlas figure. Levels resolve into the Neuro Atlas.

01

Landmarks

Iliac crest and PSIS are marked before the first session.

02

Coverage

Bilateral, working from lateral to medial.

03

Review

Field and interval are reviewed after each cycle.

Plexus lumbosacralis protocol (definitive)

HB-PLS/PROTOCOLApproved

Zones

  • Ventral: trochanter region and lateral hip
  • Ventral: TFL projection and lateral thigh chain
  • Dorsal: paravertebral L4–S2 and gluteal region
  • Dorsal: piriformis projection, SI region and proximal ITB
  1. Week 1–2

    Plexus lumbosacralis-1 (1–2× per day)

  2. Week 3

    Morning: Plexus lumbosacralis-2 · Evening: Plexus lumbosacralis-1

  3. Week 4

    Plexus lumbosacralis-2 (1–2× per day)

  4. Week 5

    Plexus lumbosacralis-2 (evening)

On relapse: reintroduce Plexus lumbosacralis-1 for 3 days.

Chapter 06

Formulation science

The scientific philosophy of the composition: sequential formulation, phase relationship and ingredient rationale.

The composition read as an architecture, with the current formula held read-only and any proposed successor documented alongside it.

Documentation metadata+

Chapter 06 — related anatomy

Declared; content in preparation.

Related documents

PFPlexus Lumbosacralis DUO — product formula cardIn preparationRM-001Ingredient libraryReservedRM-008Change controlReserved

Future references

  • Ingredient linksReservedEvery constituent resolving to its RM-001 entry.
  • Version comparisonReservedSide-by-side comparison of current and proposed composition.

Composition

Formulation architecture

The composition is documented as a map rather than a list. Every constituent is recorded with the function it carries, the reason it is present in this field, how it relates to the rest of the composition and the cutaneous topical formulation category it belongs to.

Carrier systemHumectantEmollientConditioning agentAntioxidant stabiliser
  1. 01Aqua base

    Aqua

    Carrier system

    Functional role
    Carrier phase
    Formulation purpose
    Sets the water phase that determines spreadability across a defined surface field.
    Interaction within the composition
    Holds the humectant fraction in solution and carries the emulsified lipid phase evenly over the zone.
  2. 02Glycerin

    Glycerin

    Humectant

    Functional role
    Moisture binding
    Formulation purpose
    Keeps the applied layer supple so the same field can be worked repeatedly without dryness on the skin surface.
    Interaction within the composition
    Balances the emollient fraction: the humectant governs the water phase, the emollient the lipid phase.
  3. 03Shea butter

    Butyrospermum parkii butter

    Emollient

    Functional role
    Skin-feel and occlusive body
    Formulation purpose
    Gives the texture enough body to stay on the applied zone rather than running along the hairline.
    Interaction within the composition
    Carries the lipid-soluble antioxidant fraction and slows the evaporation of the water phase.
  4. 04Panthenol

    Panthenol

    Conditioning agent

    Functional role
    Surface conditioning
    Formulation purpose
    Documented as a conditioning constituent of the cutaneous topical base; contributes to a smooth, non-tacky finish.
    Interaction within the composition
    Water-soluble; works alongside glycerin in the same phase without altering the emulsion.
  5. 05Tocopherol

    Tocopherol

    Antioxidant stabiliser

    Functional role
    Formulation stability
    Formulation purpose
    Protects the lipid fraction over the shelf life of the record so successive batches stay comparable.
    Interaction within the composition
    Dissolved in the shea fraction; stabilises the constituents it is dispersed in rather than acting on the skin.

Reading the map

Constituents are grouped by formulation category: a carrier system that governs spread, a water phase that governs feel, a lipid phase that governs stay-time, and stabilising constituents that keep successive batches comparable. Interactions describe the composition only; no physiological effect is asserted.

Cutaneous topical formulation rationale

The formulation is built for reproducible application on the documented zones: a texture that spreads thinly, a controlled sensory profile and a composition suitable for repeated professional use.

Representative composition overview. The full INCI listing is published in the composition index.

Philosophy

Formulation philosophy

Formulation philosophy: composition is selected for a defined surface field and a reproducible application sequence. The record documents composition and application only; no physiological or therapeutic mechanism is claimed.

The lumbosacral trunk carries L4 and L5 fibres into the sacral plexus. Its surface correlate is a diagonal band rather than a single dermatome, which is why the application field is described by landmarks instead of segments alone.

Chapter 07

Product formula

Linked document PF-001. The formulation master: phase formulas, ingredient records, suppliers and the current → proposed comparison.

Linked document PF — the formulation master. Ingredient data exists once, in the product formula record, and is referenced from here.

Documentation metadata+

Chapter 07 — related anatomy

Declared; content in preparation.

Related documents

PF-PLS-1.0Plexus Lumbosacralis DUO — product formula cardIn preparationRM-001Ingredient libraryReservedRM-003Approved raw materialsReserved

Future references

  • Ingredient linksReservedEvery constituent resolving to its RM-001 entry.
  • Version comparisonReservedSide-by-side comparison of current and proposed composition.

PLEXUS LUMBOSACRALIS DUO — Product Formula record

PF-008Approved
Document
PF-008
Version
1.0
Revision date
2026-08
Basis
Lanette protocol, two sequential phases of 100 g. EMG targeted (L4–S2).

Phase 1 — Release

LUMBOSACRALIS-1100 g
Intent
Afferent discharge of the paravertebral L4–S2 field, gluteal and piriformis / ITB tension reduction.
Batch size
100 g
Filling

Ingredient table — as approved in the handbook

IngredientLanette cream FNA
Source
Quantity65 g
Remark
IngredientAqua purificata
Source
Quantity18 g
Remark
IngredientMagnesium chloride
Source
Quantity3 g
Remark
IngredientMSM
Source
Quantity3 g
Remark
IngredientPEA (Vitals)
Source
Quantity2 g
Remark5 capsules, opened.
IngredientBoswellia serrata (WeightWorld)
Source
Quantity1 g
Remark2 capsules, opened.
IngredientHypericum D6
Source
Quantity0.5 g
Remark
IngredientRuta graveolens
Source
Quantity0.4 g
Remark
IngredientArnica D6
Source
Quantity0.7 g
Remark
IngredientCopaiba
Source
Quantity0.7 g
Remark
IngredientMagnesium bisglycinate
Source
Quantity1 g
Remark
IngredientSqualane
Source
Quantity2 g
Remark
IngredientBetaine TMG
Source
Quantity0.8 g
Remark
IngredientD-Panthenol
Source
Quantity0.8 g
Remark
IngredientVitamin E
Source
Quantity0.5 g
Remark
IngredientSilicea Gel
Source
Quantity2 g
Remark
IngredientCOSGARD
Source
Quantity0.7 g
Remark

Phase 2 — Integration

LUMBOSACRALIS-2100 g
Intent
Stabilisation, fascial integration and vegetative harmonisation. Plus one drop of black spruce EO.
Batch size
100 g
Filling

Ingredient table — as approved in the handbook

IngredientLanette cream FNA
Source
Quantity67 g
Remark
IngredientAqua purificata
Source
Quantity16 g
Remark
IngredientMagnesium chloride
Source
Quantity2 g
Remark
IngredientMSM
Source
Quantity2.5 g
Remark
IngredientPEA (Vitals)
Source
Quantity1.5 g
Remark
IngredientBoswellia serrata
Source
Quantity0.33 g
Remark
IngredientHypericum D6
Source
Quantity0.3 g
Remark
IngredientBacopa monnieri
Source
Quantity0.7 g
Remark
IngredientBlue Lotus
Source
Quantity0.017 g
RemarkOne drop per 300 g — scaled to the 100 g batch.
IngredientFrankincense CO2
Source
Quantity0.05 g
Remark2 drops.
IngredientQ10
Source
Quantity0.33 g
Remark
IngredientCopaiba
Source
Quantity0.6 g
Remark
IngredientMagnesium bisglycinate
Source
Quantity0.5 g
Remark
IngredientSqualane
Source
Quantity2 g
Remark
IngredientBetaine TMG
Source
Quantity0.7 g
Remark
IngredientD-Panthenol
Source
Quantity1.2 g
Remark
IngredientVitamin E
Source
Quantity0.7 g
Remark
IngredientSilicea Gel
Source
Quantity2 g
Remark
IngredientCOSGARD
Source
Quantity0.7 g
Remark
IngredientBlack spruce EO
Source
Quantity0.025 g
Remark1 drop per batch.

Ingredient cards — LUMBOSACRALIS-1

RM-001 relationship

Lanette cream FNA

65 g

Source

Not declared in the handbook

Aqua purificata

18 g

Source

Not declared in the handbook

Magnesium chloride

3 g

Source

Not declared in the handbook

MSM

3 g

Source

Not declared in the handbook

PEA (Vitals)

2 g

Source

Not declared in the handbook

5 capsules, opened.

Boswellia serrata (WeightWorld)

1 g

Source

Not declared in the handbook

2 capsules, opened.

Hypericum D6

0.5 g

Source

Not declared in the handbook

Ruta graveolens

0.4 g

Source

Not declared in the handbook

Arnica D6

0.7 g

Source

Not declared in the handbook

Copaiba

0.7 g

Source

Not declared in the handbook

Magnesium bisglycinate

1 g

Source

Not declared in the handbook

Squalane

2 g

Source

Not declared in the handbook

Betaine TMG

0.8 g

Source

Not declared in the handbook

D-Panthenol

0.8 g

Source

Not declared in the handbook

Vitamin E

0.5 g

Source

Not declared in the handbook

Silicea Gel

2 g

Source

Not declared in the handbook

COSGARD

0.7 g

Source

Not declared in the handbook

Ingredient cards — LUMBOSACRALIS-2

RM-001 relationship

Lanette cream FNA

67 g

Source

Not declared in the handbook

Aqua purificata

16 g

Source

Not declared in the handbook

Magnesium chloride

2 g

Source

Not declared in the handbook

MSM

2.5 g

Source

Not declared in the handbook

PEA (Vitals)

1.5 g

Source

Not declared in the handbook

Boswellia serrata

0.33 g

Source

Not declared in the handbook

Hypericum D6

0.3 g

Source

Not declared in the handbook

Bacopa monnieri

0.7 g

Source

Not declared in the handbook

Blue Lotus

0.017 g

Source

Not declared in the handbook

One drop per 300 g — scaled to the 100 g batch.

Frankincense CO2

0.05 g

Source

Not declared in the handbook

2 drops.

Q10

0.33 g

Source

Not declared in the handbook

Copaiba

0.6 g

Source

Not declared in the handbook

Magnesium bisglycinate

0.5 g

Source

Not declared in the handbook

Squalane

2 g

Source

Not declared in the handbook

Betaine TMG

0.7 g

Source

Not declared in the handbook

D-Panthenol

1.2 g

Source

Not declared in the handbook

Vitamin E

0.7 g

Source

Not declared in the handbook

Silicea Gel

2 g

Source

Not declared in the handbook

COSGARD

0.7 g

Source

Not declared in the handbook

Black spruce EO

0.025 g

Source

Not declared in the handbook

1 drop per batch.

Supplier links

RM-003 relationship

Sources named in the handbook. Qualification and specifications are held in the approved raw-material manual; this record shows the relationship only.

    Current → proposed

    Never merged
    FieldFormula version
    CurrentPF-008 v1.0 — approved
    ProposedReserved — no successor issued
    FieldIngredient table
    CurrentPhase 1 and phase 2 as approved in HB-PLS
    ProposedReserved — change request required (RM-008)

    Chapter 08

    Standard operating procedure

    Linked document SOP-001. The manufacturing master: workflow, equipment, quality control, packaging, traceability and release criteria.

    Linked document SOP — the manufacturing master. Process, equipment, quality control, packaging and traceability.

    Documentation metadata+

    Chapter 08 — related anatomy

    Declared; content in preparation.

    Related documents

    SOP-01Application documentationSOP-02Record revision and approvalIn preparationRM-005Manufacturing recordsReservedRM-007EquipmentReserved

    Future references

    • Batch recordsReservedExecuted batch documentation linked to each manufactured lot.
    • Deviation managementReservedRegistered deviations and corrective actions.

    PLEXUS LUMBOSACRALIS DUO — manufacturing record (Lanette protocol)

    SOP-008Approved
    Document
    SOP-008
    Version
    1.0
    Revision date
    2026-08

    Manufacturing timeline

    RM-005 relationship
    1. 01Weigh Lanette cream FNA and aqua purificata.
    2. 02Heat both to ±60 °C.
    3. 03Stir homogeneously into a stable emulsion base.
    4. 04Dissolve magnesium chloride completely.
    5. 05Dissolve MSM completely.
    6. 06Add to the base at ±50–55 °C.
    7. 07Open the PEA and Boswellia capsules.
    8. 08Pre-disperse the powders in a small amount of jojoba oil or glycerine.
    9. 09Add the dispersion below 40 °C.
    10. 10Add Bacopa, Blue Lotus and the homeopathic dilutions below 35 °C.
    11. 11Add COSGARD below 40 °C.
    12. 12Check pH: 5.2 – 5.5.
    13. 13Let the emulsion rest for 24 hours.
    14. 14Re-homogenise briefly.
    15. 15Fill into airless dispensers of 15 ml.

    Quality control

    RM-006 relationship
    pH range
    5.2 – 5.5
    Process temperature
    ±60 °C base and water phase
    Powder dispersion addition
    Below 40 °C
    Sensitive additions
    Below 35 °C
    Stabilisation
    24 hours before use

    Critical checklist

    • Magnesium chloride and MSM completely dissolved.
    • PEA and Boswellia pre-dispersed without grit.
    • Silicea gel dispersed without lumps.
    • Sensitive components and essential oils added below 35 °C only.
    • No phase separation and no air bubbles.

    Equipment

    RM-007 relationship
    • Balance for separate weighing of base and water phase
    • Heating bath / plate to ±60 °C
    • Stirring equipment for continuous homogeneous mixing without air inclusion
    • Homogeniser
    • pH measurement
    • Airless dispensers 15 ml for filling

    Batch structure

    Batch
    Phase 1 batch
    100 g
    Phase 2 batch
    100 g
    Filling
    Airless dispensers 15 ml

    Release criteria

    Release
    • pH within 5.2 – 5.5.
    • Homogeneous emulsion without phase separation.
    • No grit from PEA or Boswellia powders.
    • No air bubbles in the filled dispenser.
    • Stabilised 24 hours before release.

    Traceability

    Record
    Developer
    MT DO, DCP
    Pharmacist
    AVA
    Manufacturing records
    RM-005 — relationship only
    Quality assurance
    RM-006 — relationship only

    Chapter 09

    Reference manuals

    RM-001 → RM-010. The quality management library this record is connected to, referenced by relationship only.

    The reference manual library RM-001 → RM-010, connected to this record by relationship only.

    Documentation metadata+

    Chapter 09 — related anatomy

    Declared; content in preparation.

    Future references

    • Manual publicationReservedReference manuals published as controlled documents.

    Documentation hub — reference manuals

    Relationships only

    RM-001

    Ingredient library

    Single source for every constituent used in a formulation.

    RM-002

    Formula matrix

    Composition matrix across families and versions.

    RM-003

    Approved materials

    Qualified raw materials and their specifications.

    RM-004

    Inventory

    Material positions, lots and expiry tracking.

    RM-005

    Manufacturing

    Process documentation and manufacturing instructions.

    RM-006

    Quality assurance

    Release checks, deviations and corrective actions.

    RM-007

    Equipment

    Equipment identity, qualification and maintenance.

    RM-008

    Change control

    Governance of proposed versions and their approval.

    Reference manual integration

    Architecture only
    • RM-001Ingredient librarySingle source for every constituent used in a formulation.
    • RM-002Formula matrixComposition matrix across families and versions.
    • RM-003Approved materialsQualified raw materials and their specifications.
    • RM-004InventoryMaterial positions, lots and expiry tracking.
    • RM-005ManufacturingProcess documentation and manufacturing instructions.
    • RM-006Quality assuranceRelease checks, deviations and corrective actions.
    • RM-007EquipmentEquipment identity, qualification and maintenance.
    • RM-008Change controlGovernance of proposed versions and their approval.
    • RM-009StabilityStability programme and observation intervals.
    • RM-010Clinical outcomesStructured observation framework for practitioners.

    Chapter 10

    QR patient information

    The label surface, generated from the digital record: what the formulation is, its timeline, application areas, safety and quality assurance.

    The label surface of the record, generated from the digital record so patient information can never drift from the documentation.

    Documentation metadata+

    Chapter 10 — related anatomy

    Iliac crest linePosterior superior iliac spineUpper gluteal quadrantSacroiliac projection

    Related documents

    Appendix DQR standardReserved

    Future references

    • Printed QRReservedProduction-ready QR code bound to the published version.

    Documentation

    Downloads

    • Plexus application protocolsPDF · 1.5 MB · ProfessionalRequest →
    • Composition and ingredient indexPDF · 0.9 MB · OpenRequest →
    • QR label packZIP · 6.1 MB · ProfessionalRequest →

    Label

    QR resources

    Each package carries a QR code that resolves to this documentation record in the reader's language, together with the composition index and the current application protocol. Codes are versioned, so updated documentation reaches practitioners without relabelling.

    Resolves to /products/plexus-lumbosacralis-duo

    QR information

    Label resource
    Current QR resolves to
    /products/plexus-lumbosacralis-duo
    Current version
    1.0
    Last update
    2025-09
    Batch number
    PLS-2509

    Storage information

    Store closed, upright and away from direct sunlight. Storage conditions are documented on the label and repeated here without alteration.

    Professional information

    Professional reading opens the complete monograph: anatomy, composition architecture, protocol and revision record.

    Patient information

    Essential reading describes what the composition is, where it is applied and in which order, without clinical interpretation.

    • Multilingual QR contentReservedReserved: Dutch, English, French and German resolution of the same record.

    Chapter 11

    Professional documentation

    The controlled document set of this record: references, questions, governance and search metadata.

    The document hub of the record. Each document exists once in the controlled set and is referenced from here.

    Documentation metadata+

    Chapter 11 — related anatomy

    Declared; content in preparation.

    Future references

    • Digital signatureReservedSigned approval attached to the published version.

    Education

    Educational references

    • Surface field mapping — method noteLandmark-based definition of application fields.SIRIAM LAB, internal documentation
    • Segmental innervation referenceDermatome, nerve and metamer objects used by this record.SIRIAM LAB Neuro Atlas dataset

    FAQ

    Frequently asked questions

    Is this a medicinal product?

    No. SIRIAM formulations are cutaneous topical compositions. They are described by application region and composition, not directed at a therapeutic indication but rather at regulation of the nervous system. EMG validation will need to support this further in the future.

    Who determines the application region?

    The region is identified by a healthcare professional using anatomical landmarks and surface maps. Our documentation supports that conversation.

    Can the formulation be combined with other routines?

    Combination and sequencing are decided together with the treating professional. We document composition, application and response.

    Document hub

    One source per document

    Handbook placement

    Chapter
    Plexus Lumbosacralis DUO record
    Subchapter
    Anatomy, purpose, protocol, composition, documentation

    Citations

    • CitationsReservedFormal citation of this record inside handbook chapters.

    Document hierarchy

    Individually version-controlled
    1. HB-PLSHandbook chapter — scientific master
    2. SDR-001Digital record — presentation source
    3. PF-008Product formula — formulation master
    4. INGIngredient cards — derived from the formula
    5. SUPSupplier links — RM-003 relationship
    6. SOP-008Manufacturing record
    7. RMReference manuals — relationships only
    8. ATLASNeuro Atlas — anatomical relationships
    9. RESEARCHResearch modules
    10. QRQR record — patient presentation

    Every document carries its own version. Revising the formula does not modify the digital record; revising the manufacturing record does not modify the formula.

    Governance of this record

    Responsible author
    SIRIAM LAB documentation team
    Scientific reviewer
    Scientific review board
    Approval status
    Approved
    Release date
    2026
    Revision date
    2025-09
    Digital signature
    Reserved

    Record metadata

    Prepared for search

    Region

    lumbar

    Dermatomes

    L4L5S1S2

    Peripheral nerves

    sciaticsuperior-glutealpudendal

    Plexus

    lumbarsacral

    Metamers

    L4L5S1S2

    Clinical goal

    Segmental orientationStructured daily applicationProfessional protocol support

    Ingredients

    Aqua baseGlycerinShea butterPanthenolTocopherol

    Therapeutic category

    Cutaneous topical composition

    Product family

    PLEXUS LUMBOSACRALIS DUO

    Current version

    1.0

    Documentation

    SIR-PLS-01

    Research

    method-overviewsurface-mappingfunctional-emg-mapping

    SDR header — product identity

    SDR-001 · v1.0 · Frozen

    The identification block of the record. Every renderer reads these fields; none of them is restated elsewhere.

    Product name

    Plexus Lumbosacralis DUO

    Product code

    PLS

    Product family

    PLEXUS

    Product category

    Cutaneous topical composition

    Current formula version

    1.0

    Documentation version

    1.0

    QR version

    1.0

    Scientific status

    Established

    Documentation status

    Documented

    Clinical status

    Documented — cutaneous topical composition, no therapeutic claim

    Approval status

    Approved

    Last revision

    2025-09

    Responsible institute

    SIRIAM LAB — European institute for neurodermal science

    Responsible author

    SIRIAM LAB documentation team

    Scientific reviewer

    Scientific review board

    Current language

    English (EN)

    Additional languages

    ReservedDutch, French and German resolution of the same record.

    Product identifier

    SIR-PLS-01

    Executive summary

    SDR-001

    The reading entry of the record: what the composition is for, in professional and in patient language.

    Purpose

    Supports a structured routine across a field that is otherwise difficult to define, by anchoring the application to two reproducible bony landmarks.

    Clinical goal

    Segmental orientationStructured daily applicationProfessional protocol support

    Primary anatomical region

    lumbar

    Primary therapeutic objective

    Documented cutaneous topical composition for the lumbosacral transition field.

    Professional summary

    Plexus Lumbosacralis DUO is documented as a cutaneous topical composition for the lumbar application field. This summary is maintained by the documentation team and updated with each revision of the record.

    Patient summary

    Transition concept for the lumbosacral field, where lumbar and sacral territories meet across the pelvic rim.

    Keywords

    Plexus Lumbosacralis DUOPLEXUSlumbarL4L5S1S2lumbarsacral

    Anatomical record

    SDR-001

    Anatomy is held once in the Neuro Atlas. This section declares which atlas objects the record belongs to.

    Primary region

    lumbar

    Body region

    lumbar

    Dermatomes

    L4L5S1S2

    Peripheral nerves

    sciaticsuperior-glutealpudendal

    Plexus

    lumbarsacral

    Metameres

    L4L5S1S2

    Neurocutaneous territories

    lumbosacralsacral

    Embryological layer

    ReservedSegmental embryological derivation of the field.

    Related regions

    lumbar

    Future EMG mapping

    ReservedFunctional EMG dataset linked to the segmental levels of this record.

    Future SRST mapping

    ReservedSegmental reflex surface topography mapping.

    Future atlas reference

    ReservedVolumetric atlas reference of the application field.

    Clinical record

    SDR-001

    The documented boundaries of the record. Statements are descriptive; no therapeutic effect is claimed.

    Clinical objective

    Supports a structured routine across a field that is otherwise difficult to define, by anchoring the application to two reproducible bony landmarks.

    Primary indications

    Segmental orientationStructured daily applicationProfessional protocol support

    Secondary indications

    lumbosacralsacral

    Contraindications

    Not applied to broken, irritated or recently treated skin, nor to the eye region. Documented per session by the treating professional.

    Warnings

    Cutaneous topical composition. Information is provided for education and professional reference; it is not medical advice and implies no therapeutic effect.

    Expected response

    Sensory and cutaneous topical observations only, recorded in the professional log so successive periods remain comparable.

    Treatment phase

    Application — Single-phase applicationMaintenance — Continued routine

    Evidence status

    ReservedGraded evidence classification per documented statement.

    Professional notes

    The field spans two plexus territories; document which landmark line was used so sessions remain comparable.Cutaneous topical composition; the application field is defined by the treating professional.

    Patient notes

    Identify the posterior superior iliac spines as the reference line.Apply along the iliac crest toward the sacroiliac projection.Cover the upper gluteal quadrant with even, unhurried passes.

    Application record

    SDR-001

    The reproducible application of the record: field, sequence, cadence and handling.

    Application zone

    Iliac crest linePosterior superior iliac spineUpper gluteal quadrantSacroiliac projection

    Application method

    01 — Landmarks02 — Coverage03 — Review

    Treatment frequency

    1–2 applications per day

    Treatment duration

    Defined observation period

    Maintenance

    The routine is continued at a reduced cadence and reviewed with the practitioner at agreed intervals. Observations stay in the professional log so successive periods remain comparable.

    Patient instructions

    Identify the posterior superior iliac spines as the reference line.Apply along the iliac crest toward the sacroiliac projection.Cover the upper gluteal quadrant with even, unhurried passes.

    Professional instructions

    Iliac crest and PSIS are marked before the first session.Bilateral, working from lateral to medial.Field and interval are reviewed after each cycle.

    Storage

    Stored closed, upright and away from direct sunlight. Storage conditions are documented on the label and repeated here without alteration.

    Shelf-life

    ReservedStability programme of RM-009 determines the documented shelf-life.

    Packaging

    PLEXUS presentation; batch PLS-2509.

    Formulation record

    SDR-001

    The current formula is read-only. A proposed successor is held alongside it and never merged into it.

    Formulation philosophy

    Formulation philosophy: composition is selected for a defined surface field and a reproducible application sequence. The record documents composition and application only; no physiological or therapeutic mechanism is claimed.

    Scientific rationale

    The lumbosacral trunk carries L4 and L5 fibres into the sacral plexus. Its surface correlate is a diagonal band rather than a single dermatome, which is why the application field is described by landmarks instead of segments alone.

    Current formula

    1.0 — Initial approved composition.

    Mechanism

    Formulation philosophy: composition is selected for a defined surface field and a reproducible application sequence. The record documents composition and application only; no physiological or therapeutic mechanism is claimed.

    Manufacturing notes

    ReservedProcess documentation held in RM-005.

    Quality notes

    ReservedRelease checks and deviations held in RM-006.

    Current PF

    PF-PLS-1.0

    Current formula version

    1.0

    Future formula

    ReservedNo proposed successor is currently held for this record.

    Future change request

    ReservedChange requests are governed by RM-008.

    Ingredient table

    Read-only — current formula
    ConstituentAqua base
    RoleCarrier phase
    PurposeSets the water phase that determines spreadability across a defined surface field.
    CategoryCarrier system
    ConstituentGlycerin
    RoleMoisture binding
    PurposeKeeps the applied layer supple so the same field can be worked repeatedly without dryness on the skin surface.
    CategoryHumectant
    ConstituentShea butter
    RoleSkin-feel and occlusive body
    PurposeGives the texture enough body to stay on the applied zone rather than running along the hairline.
    CategoryEmollient
    ConstituentPanthenol
    RoleSurface conditioning
    PurposeDocumented as a conditioning constituent of the cutaneous topical base; contributes to a smooth, non-tacky finish.
    CategoryConditioning agent
    ConstituentTocopherol
    RoleFormulation stability
    PurposeProtects the lipid fraction over the shelf life of the record so successive batches stay comparable.
    CategoryAntioxidant stabiliser

    Documentation record

    SDR-001

    Each document exists once in the controlled set and is referenced from here; nothing is duplicated.

    Product formula

    PF-PLS-1.0

    Reference manuals

    RM-01 — Anatomical reference manualRM-02 — Formulation record manual

    Standard operating procedures

    SOP-01 — Application documentationSOP-02 — Record revision and approval

    Appendices

    Appendix A — TerminologyAppendix B — Identifiers and codes

    Handbook chapters

    Part IV — Formulation records · Plexus Lumbosacralis DUO record

    Downloads

    dl-protocol-plexusdl-ingredientsdl-qr

    Scientific references

    Surface field mapping — method note — SIRIAM LAB, internal documentationSegmental innervation reference — SIRIAM LAB Neuro Atlas dataset

    QR information

    /products/plexus-lumbosacralis-duo

    Version history

    1.0 · 2026

    Connected knowledge

    SDR-001

    The record as a node of the knowledge network. Relationships are declared here and resolved by the graph.

    Related products

    plexus-lumbalissx-duotlo-duo

    Related anatomical structures

    region: lumbarplexus: lumbarplexus: sacralnerve: sciaticnerve: superior-glutealnerve: pudendalmetamer: L4metamer: L5metamer: S1metamer: S2

    Related dermatomes

    L4L5S1S2

    Related peripheral nerves

    sciaticsuperior-glutealpudendal

    Related plexuses

    lumbarsacral

    Related ingredients

    Aqua baseGlycerinShea butterPanthenolTocopherol

    Related publications

    Scientific publications

    Related research

    method-overviewsurface-mappingfunctional-emg-mapping

    Related RM

    RM-01RM-02

    Related SOP

    SOP-01SOP-02

    Future clinical cases

    ReservedStructured practitioner observations connected to this record.

    Future AI suggestions

    ReservedAutomatically proposed relationships, reviewed before publication.

    QR record

    SDR-001

    The product page is the official destination of every QR code printed on the packaging.

    QR status

    Active

    QR version

    1.0

    QR URL

    /products/plexus-lumbosacralis-duo

    QR created

    2026

    QR last updated

    2025-09

    Current batch

    PLS-2509

    Current product version

    1.0

    Patient information

    Essential reading describes what the composition is, where it is applied and in which order, without clinical interpretation.

    Professional information

    Professional reading opens the complete monograph: anatomy, composition architecture, protocol and revision record.

    Version record

    SDR-001

    The current version is never overwritten. Every superseded version is archived and retained.

    Current version

    1.0

    Previous version

    None recorded

    Next planned version

    ReservedNo successor is currently planned.

    Revision date

    2025-09

    Change requests

    ReservedChange control is governed by RM-008.

    Approval workflow

    Current → proposed → scientific review → approval → publication → archive.

    Archive

    1 documented version retained.

    Archive

    Retained
    Version1.0
    Date2026
    ChangeInitial documentation record published in the Product Library.

    Search metadata

    SDR-001

    The flat index of the record, prepared for platform search and future APIs.

    Region

    lumbar

    Dermatomes

    L4L5S1S2

    Peripheral nerves

    sciaticsuperior-glutealpudendal

    Plexus

    lumbarsacral

    Metamers

    L4L5S1S2

    Clinical goal

    Segmental orientationStructured daily applicationProfessional protocol support

    Ingredients

    Aqua baseGlycerinShea butterPanthenolTocopherol

    Therapeutic category

    Cutaneous topical composition

    Product family

    PLEXUS LUMBOSACRALIS DUO

    Current version

    1.0

    Documentation

    SIR-PLS-01

    Research

    method-overviewsurface-mappingfunctional-emg-mapping

    Digital relationships

    Architecture only
    • PFProduct formula card PF-PLS-1.0In preparationOne formula card per version; referenced, never duplicated.
    • RM-001Ingredient libraryReservedSingle source for every constituent used in a formulation.
    • RM-002Formula matrixReservedComposition matrix across families and versions.
    • RM-003Approved materialsReservedQualified raw materials and their specifications.
    • RM-004InventoryReservedMaterial positions, lots and expiry tracking.
    • RM-005ManufacturingReservedProcess documentation and manufacturing instructions.
    • RM-006Quality assuranceReservedRelease checks, deviations and corrective actions.
    • RM-007EquipmentReservedEquipment identity, qualification and maintenance.
    • RM-008Change controlReservedGovernance of proposed versions and their approval.
    • RM-009StabilityReservedStability programme and observation intervals.
    • RM-010Clinical outcomesReservedStructured observation framework for practitioners.
    • SOP-01Application documentationPublishedProcedure referenced by this record.
    • SOP-02Record revision and approvalIn preparationProcedure referenced by this record.
    • Appendix ATerminologyPublishedControlled appendix of the documentation set.
    • Appendix BIdentifiers and codesPublishedControlled appendix of the documentation set.
    • ATLASNeuro AtlasPublishedAnatomical objects of this record.
    • HANDBOOKPart IV — Formulation recordsPublishedHandbook placement of this record.
    • QRQR resourcePublishedOfficial destination of the printed QR code.
    • PUBScientific publicationsReservedPublications citing this record.

    Chapter 12

    Knowledge graph

    This record as a node of the knowledge network: products, anatomy, atlas structures, ingredients and documents.

    This record as a node of the knowledge network: related products, anatomy, research, handbook parts and documents.

    Documentation metadata+

    Chapter 12 — related anatomy

    L4L5S1S2

    Future references

    • AI suggestionsReservedAutomatically generated relationship proposals reviewed before publication.
    • Clinical casesReservedCase records connected to this formulation.

    Research

    Related research modules

    Chapter 13

    Version history

    Current version, previous versions, change requests, scientific review, approval, publication and archive.

    Version control of the record: current version, previous versions, change requests, review, approval, publication and archive.

    Documentation metadata+

    Chapter 13 — related anatomy

    Declared; content in preparation.

    Related documents

    RM-008Change controlReserved

    Future references

    • ArchiveReservedImmutable archive of superseded versions.

    Record

    Version history

    1. v1.0 · 2026Initial documentation record published in the Product Library.

    Version record

    SDR-001

    The current version is never overwritten. Every superseded version is archived and retained.

    Current version

    1.0

    Previous version

    None recorded

    Next planned version

    ReservedNo successor is currently planned.

    Revision date

    2025-09

    Change requests

    ReservedChange control is governed by RM-008.

    Approval workflow

    Current → proposed → scientific review → approval → publication → archive.

    Archive

    1 documented version retained.

    Archive

    Retained
    Version1.0
    Date2026
    ChangeInitial documentation record published in the Product Library.

    Version lifecycle

    Traceability
    1. 01Current versionApproved and published; read-only.Published
    2. 02Proposed versionHeld alongside the current version, never merged into it.In preparation
    3. 03Scientific reviewReview of the proposal against the reference manuals.Reserved
    4. 04ApprovalFormal approval by the scientific reviewer.Reserved
    5. 05PublicationThe approved version becomes the current version.Reserved
    6. 06ArchiveThe superseded version is retained for traceability.Reserved

    The current version is never overwritten. A proposed version is held as a separate object; superseded versions are archived and retained.

    Chapter 14

    Appendices

    Supplier list, ingredient classification, document coding, QR standard and glossary.

    Supporting registers of the handbook: suppliers, ingredient classification, document coding, the QR standard and the glossary.

    Documentation metadata+

    Chapter 14 — related anatomy

    Declared; content in preparation.

    Future references

    • Supplier qualificationReservedQualification status per supplier, held in RM-003.

    Appendix A — Supplier list

    Derived from PF-008

    No supplier declared in the current formula record. Qualification status is held in RM-003.

    Appendix B — Ingredient classification

    Base
    Carrier phase determining spreadability and dermal contact time.
    Functional
    Constituent selected for the documented functional intent of the phase.
    Modulating
    Constituent adjusting tolerance, texture or release of the phase.
    Sensory
    Constituent determining the sensory signature of the application.

    Appendix C — Document coding

    HB-…
    Handbook chapter — the scientific master.
    SDR-…
    SIRIAM digital record — the digital product record.
    PF-…
    Product formula — the formulation master.
    SOP-…
    Standard operating procedure — the manufacturing master.
    RM-…
    Reference manual — the quality management master.

    Appendix D — QR standard

    Source
    Patient information is generated from the digital record; it is never written separately.
    Scope
    Product identity, treatment goal, timeline, application areas, safety and quality assurance.
    Binding
    Each published QR surface is bound to one approved record version.

    Appendix E — Glossary

    Neurodermal
    The relationship between segmental innervation and the cutaneous surface.
    DUO
    A sequential formulation applied in two documented phases.
    Metamere
    The segmental unit linking dermatome, myotome, sclerotome and viscerotome.
    SRST
    Segmental reflex surface topography.

    Quality system

    Version control

    The current composition and any proposed successor are documented side by side. Approval and change control are handled outside the platform.

    Current formula

    Approved
    Version
    1.0
    Revision date
    2025-09

    Initial approved composition.

    Proposed formula

    Not issued

    No successor is currently proposed for this record.

    QR information

    Active
    QR target
    /products/plexus-lumbosacralis-duo
    Batch reference
    PLS-2509
    Record status
    Documented

    The QR code printed on the label resolves to this record. The product page is the single source of truth; printed material never carries content that is not documented here.

    Controlled documents →

    Continue

    Explore further

    Cutaneous topical formulation. Information is provided for education and professional reference; it is not medical advice and implies no therapeutic effect.

    Back to the ecosystem →

    Knowledge graph

    Related knowledge

    Everything connected to this formulation: anatomy, application zones, ingredients, protocols, research and documentation.